Abstract
Cinnamides as novel CCR1 antagonist chemotypes are described with high affinity to human and rodent receptors. A1B1 and A4B7 showed oral activity in the mouse collagen induced arthritis.
MeSH terms
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Administration, Oral
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
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Anti-Inflammatory Agents, Non-Steroidal / chemistry*
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
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Arthritis, Experimental / drug therapy*
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Humans
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Mice
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Rats
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Receptors, CCR1
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Receptors, Chemokine / antagonists & inhibitors*
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Structure-Activity Relationship
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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CCR1 protein, human
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Ccr1 protein, mouse
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Ccr1 protein, rat
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Receptors, CCR1
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Receptors, Chemokine